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The brain health library.
Eighteen plain-language explainers on how the brain maintains itself, what goes wrong in disease and aging, where the science is heading, and how to read the evidence. Every figure carries its source and year. Videos come from research institutions and play only when you choose.
Foundations
The systems that keep a brain healthy: clearance, energy, blood vessels, immunity and sleep.
What is brain clearance?
Brain cells produce waste all day. The brain has a dedicated plumbing system to carry it away, and it runs mostly while you sleep.
FoundationsClearance biology: the glymphatic system
A closer look at the anatomy: perivascular spaces, astrocytes, aquaporin-4 and the meningeal lymphatics that finish the job.
FoundationsSleep and the brain’s night shift
Deep sleep is when the brain’s fluid system works hardest. Here is what the measurements actually show, in mice and in people.
FoundationsNeuroinflammation
The brain’s immune cells protect it, prune it and clean it. When their activity becomes chronic, it is associated with nearly every neurodegenerative disease.
FoundationsPhysiological resilience
Sleep, blood vessels, metabolism and cellular housekeeping determine how well the brain absorbs stress and recovers. These systems are measurable and, to a degree, trainable.
FoundationsMitochondria and brain energy
The brain runs on a fifth of the body’s energy, made by trillions of tiny power plants. When they falter, neurons are the first to feel it.
FoundationsBlood vessels and the brain
Four hundred miles of vessels, a barrier that guards every one of them, and the strongest evidence we have for protecting the brain in midlife.
FoundationsNeuroplasticity and repair
The adult brain is not fixed. It rewires with experience, grows new connections after injury, and may even make new neurons. Here is what is established and what is still argued.
Conditions and aging
The diseases and life stages where clearance matters most.
Alzheimer’s disease
The most common cause of dementia, affecting an estimated 7.4 million Americans aged 65 and over, with a human and economic burden that extends far beyond the person diagnosed.
Conditions and agingParkinson’s disease
The second most common neurodegenerative disease, with more than 8.5 million people affected worldwide, and one where energy, protein handling and clearance all appear to fail together.
Conditions and agingHealthy aging
Aging changes the brain, but aging is not dementia. Understanding the normal changes helps separate what is inevitable from what is modifiable.
Conditions and agingWhy does aging matter?
Age is the single largest risk factor for neurodegenerative disease. The reasons are becoming clearer, and some of them are mechanical.
Conditions and agingCognitive performance
Attention, memory and decision-making are not fixed traits. They respond, within hours, to sleep, environment and physiology.
Frontiers
Where the science is moving: recent advances, longevity biology and extreme environments.
The biology of longevity
Aging is no longer a black box. Twelve measurable processes drive it, and for the first time researchers are testing whether they can be slowed.
FrontiersRecent advances, 2023 to 2026
A plain-language digest of what has actually changed in brain-health science in the last three years: new treatments, a blood test, a barrier opened on purpose, and an important negative result.
FrontiersWhat changes in microgravity?
Spaceflight shifts fluid toward the head and changes the brain’s shape and the eye’s structure. It is an extreme natural experiment in brain fluid dynamics.
Reading guides
Tools for weighing evidence and understanding the vocabulary.
About this library
Educational content here summarises published, third-party research in general terms. It is not medical advice and is not evidence that any NeuroClearance system works. We say mouse when we mean mouse, and we flag small studies as small. Corrections are welcome at [email protected].